New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase
نویسندگان
چکیده
منابع مشابه
Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK.
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were from the Manchester area of the UK and were obtained in 1990, 1991 and 1993. The gene segment was amplified by the polymerase chain reaction u...
متن کاملEfficacy of the novel parainfluenza virus haemagglutinin-neuraminidase inhibitor BCX 2798 in mice - further evaluation.
BACKGROUND Human parainfluenza virus type 1 (hPIV-1) causes serious respiratory tract infections, especially in children. This study investigated the efficacy of the novel haemagglutinin-neuraminidase (HN) inhibitor BCX 2798 in the prophylaxis of lethal and the treatment of non-lethal parainfluenza virus infection in mice. METHODS In the prophylaxis model, 129x1/SvJ mice were inoculated with ...
متن کاملThe Design, Synthesis and Assessment of Novel Haemagglutinin- Neuraminidase Inhibitors
i Statement of Originality ix Acknowledgements xi Communications and Publications xiii Abbreviations xv Table of Figures xix Table of Tables xxiii Nomenclature xxv CHAPTER
متن کاملSendai virus-like particles devoid of haemagglutinin-neuraminidase protein infect cells via the human asialoglycoprotein receptor.
Virus-like particles with genetically defined envelope proteins were generated from cDNA in order to examine the requirement of Sendai virus haemagglutinin-neuraminidase (HN) protein for particle formation, and the role of fusion protein (F) in receptor binding and membrane fusion. Characterization of particles devoid of HN protein showed that particle formation was unimpaired by the absence of...
متن کاملHemagglutinin-neuraminidase gene sequence-based reclassification of human parainfluenza virus 3 variants.
The most comprehensive phylogenetic classification of human parainfluenza virus 3 (HPIV-3) was recently developed [PLoS One 2012;7:e43893]. This classification included three distinct clusters (A, B and C) with subdivision of cluster C into four subclusters (C1-4). In the present report, the classification of HPIV-3 was refined by inclusion of 27 overlooked beside newly characterized Saudi vari...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2019
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2019.04.001